How Bacillus Subtilis Benefits Your Gut

Dr. Evan Goldstein

fundamentals April 20, 2023

It's true — anal sex, butt play, and your diet all have an impact on your rectal microbiome. With 95% of the body's microbiota residing in the gut, taking care of your backside starts with what you put in your body. Powerful probiotics like Bacillus subtilis are beneficial strains of bacteria that can improve your GI tract. So whether you're enjoying an afternoon romp in the sheets or a little rimming, these probiotics can help you feel confident from start to (literal) finish. Keep reading to learn more about the benefits of Bacillus subtilis, which can help reduce inflammation and strengthen your gut barrier.

What is Bacillus subtilis DE111?

Bacillus subtilis DE111 is a spore-forming bacteria that offers numerous benefits for the GI tract. It can be consumed through supplements, food, or drink. B. subtilis strains are also naturally present in various foods such as Korean kimchi, Egyptian kishk, and miso. Found in nature in soil, it has been extensively studied in clinical settings due to its ability to stimulate the immune system and promote balance in the digestive system.

What are the health benefits of Bacillus subtilis DE111?

Bacillus subtilis DE111 combats pathogens in the gut and can re-sporulate in the gut, ensuring longevity. B.subtilis germinates in the small intestine, facilitating digestive and immune health. Its effects are noticeable in a short amount of time, with colonization in the small intestine taking place in as little as three hours.

1. Gut health

While Bacillus subtilis is not naturally present in the gut, it can survive in the intestinal tract when consumed through food or supplements. This bacterium colonizes the small intestine and is particularly abundant in the jejunum and ileum. In a study that involved treating elderly individuals with Bacillus strains for 28 days, it was found that there was an increase in several types of good bacteria and organic acid production.

2. Promotes immunity

There’s nothing worse than spending days curled up in bed with a stomach ache when you could be slaying the day away! Thankfully, probiotics are known to enhance the immune system by safeguarding it against viruses and diseases. Bacillus subtilis is one such probiotic that can modulate the host's immune response. It has been found to combat respiratory illnesses and secrete enzymes, antioxidants, vitamins, peptides, and antimicrobial compounds. In one study, Bacillus strains were found to decrease the frequency of respiratory infections in participants who consumed the DE111 probiotic.

3. Reduces inflammation

Lipids in the blood are essential in the body as they help form lipoproteins and provide energy. However, when plaque builds up in the arteries, it can trigger an inflammatory response. One study found that Bacillus subtilis reduced non-HDL cholesterol levels and improved LDL (the "bad" type of cholesterol) in study participants.

4. Sexual benefits

When it comes to enjoying anal sex between the sheets (or against the kitchen counter), a healthier digestive system can help you to prepare better. Studies have shown that consuming Bacillus subtilis DE111 can lead to improvements in digestion, metabolism, and immune health within just a few hours. Bacillus subtilis can also replicate in the gut microbiome, helping to regulate bowel movements so you can better prepare for the night ahead — wherever it takes you.

5. Additional benefits

In addition to aiding digestion and boosting immune function, Bacillus subtilis DE111 has a variety of other potential health benefits. A study found that Bacillus subtilis can lower glucose levels and help maintain healthy triglyceride and cholesterol levels. Furthermore, it was shown to enhance glucose tolerance, which could be particularly valuable for individuals with diabetes or those who are at risk of developing it.

How is Bacillus subtilis DE111 different from other probiotic strains?

Bacillus subtilis is a unique microorganism that can form spores, enhance immune function, and prevent the growth of harmful pathogens, making it a valuable tool for protecting the digestive system. It is also viable in different temperatures, allowing it to be used in a wide variety of supplements and food products. Bacillus subtilis has been shown to promote regularity and maintain healthy levels of cholesterol, glucose, and triglycerides even during stressful periods. Additionally, certain strains of Bacillus subtilis are involved in the production of vitamins that can further support immune health.

Future Method’s Daily Pre + Probiotic with Bacillus subtilis DE111

Future Method’s Butt & Gut Daily Pre + Probiotic features ingredients like DE111® Bacillus subtilis supplement to help aid in digestive and immune function. Our pre + probiotic is a powerful solution for everything from booty play to anal sex, and everything in buttween.

About the author

Dr. Evan Goldstein is the Co-Founder of Future Method and the Founder and CEO of Bespoke Surgical, the leading private practice in health and wellness for gay men. He received his MD from the University of Medicine and Dentistry School of Osteopathic Medicine. Dr. Goldstein is the go-to butt and bottoming expert, having been published in Huffington Post, Men’s Health, Healthline, and more. Learn about Dr. Goldstein by visiting his practice,


Discover the cleansing solution for worry-free bottoming.

Shop Now